Macrosomia refers to increased body and limbs size, which is the most commonly identified feature of LOS 2, 17, 18. Although there is a lack of published reports providing the incidence of LOS in ART-produced offspring, through personal communications (Rocio M Rivera), this incidence has been reported to being as high as 10%. LOS can affect the dam and cause death of the afflicted animal bringing financial loss to producers. Features of LOS include overgrowth, enlarged tongues, umbilical hernias, muscle and skeleton malformation, abnormal organ growth, allantois development defects, abnormal placental vasculature, and even increased early embryo or fetus death rates 15– 18. There are many ART-induced LOS calf reports from experimental studies 10– 14. LOS refers to a group of abnormal phenotypes occurring in bovine and ovine fetuses, placentas and newborns produced by assisted reproductive technologies (ART). A greater risk of tumorigenesis is a shared feature of many OGS found in human 1.Ī generalized congenital OGS in bovine is known as large offspring syndrome (LOS 2 Figure 1). OGS can also be characterized as congenital and/or postnatal according to the age when phenotypes present 4, 7– 9. On the other hand, localized/partial OGS results in overgrowth in to one or few organs or regions of the body 6. Generalized OGS are often characterized by a 2–3 standard deviations increase in overall growth parameters including body weight, height, and head circumference 4, 5. According to the definitions used in human, OGS can be divided into two categories based on phenotypes, which are generalized OGS and localized/partial OGS 1. Overgrowth syndromes (OGS) refer to a heterogeneous group of conditions found in many species 1– 3, which show a common feature of excessive growth.
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The Municipal Corporation of Delhi has sanctioned nine new projects, including a six-lane flyover at the Upper Ridge Road and a six-lane underpass on Shankar Road. You can make a new report in the same location.MCD sanctions 9 new projects under JNNURM new parking lots to come up, Pushp Vihar drain to be covered Posted anonymously at 09:26, Tue 5 January 2021 There does not appear to be any 'joined up thinking' here, I work for an essential services provider for NHS Trusts, HMPs and other government departments however we cannot get to work if routes into London are closed off without consideration over how people will actually get into London, the mains water works have been failing to progress since the beginning of December however the works on the A2 could have been delayed, as could the mains water works on the A13, or any number of the above traffic management methods could have been implemented. The works appear to be progressing without any consideration for road users especially as the a2 which is the only other route into Town has also had a lane restriction brought into place. The Beckton A406 roundabout underpass is closed even when there are no workers or works progressing on the underpass itself and the works are actually by the. Their should be multiple gangs of workers to reduce completion time, on rotating shifts to reduce completion time or alternatively if the works are to be carried out as they are at the moment with very few workers actually completing works then they should be completed during low traffic times with lanes opened when workers are not on site to ensure traffic can flow when work is not progressing. The works should be being undertaken to reduce the impact to tax paying road users. The management of these works is non-existent. They had their lights flashing and could not make headway against the sheer volume of traffic. I was sat in the traffic this morning for over 2 hours and I was sat in teh same traffic as an ambulance on an emergency call. The works have not been completed during the festive period when there was less traffic and no roadworks have actually been being undertaken during the festive season or out of hours to ensure that the lanes could be opened when most of the traffic is trying to use the roads. Posted by TfL at 15:50, Tue 15 December 2020 Should you need anything else or have any questions please contact customer services on 03 Thank you for taking the time to report this to us. Being a fast road, there are no issues with regards to cyclist and pedestrian movements. There are no significant delays to bus services in the area. Traffic impact is currently serious, with delays on approach and westbound tailbacks to the Goresbrook Interchange. We continue to liaise closely with Thames Water and our contractors responsible for the A13. For safety reasons speed restrictions were implemented of 30mph and the relevant signage is in place on approach. We have increased VMS signage throughout the area. Our engineers have developed bespoke signal timing plans, as required, in order to mitigate any further delays and disruption. This closure has now been removed, restoring the previous traffic management as detailed above. The westbound carriageway was fully closed at Beckton Roundabout earlier last night to facilitate a phase of the repairs. Works to the 36 inch main took place over the weekend and have been extended due to further complications to the repairs. The traffic management on the westbound carriageway begins from the underpass underneath Beckton Roundabout, where the road is reduced to one lane (from two). Thames Water contractors continue to carry out works to the burst water main, working in the central reservation, hence closure of lanes on both carriageways for safety reasons. This is in place to facilitate remedial works to a burst water main. A13 Newham Way continues to have lane restrictions at Beckton Flyover, which is reduced to two lanes (from three) on both the eastbound and westbound carriageways. |
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